A Case of Atransferrinemia and 35 Cases of Hypotransferrinemia As Determined by Radioassay of Total Iron-binding Capacity of the Serum
1975 Volume 16 Issue 11 Pages 1036-1043
Details
1975 Volume 16 Issue 11 Pages 1036-1043
Total iron-binding capacity of the serum (TIBC) was determined by radioassay method developed by Saito.
Fifty μg/dl (38 mg/dl as transferrin) of TIBC, which is as low as in the cases of congenital atransferrinemia was found in a patient having a high plasma RISA disappearance rate. A similar ferrokinetics pattern was observed between the present case and the cases of congenital atransferrinemia.
In addition, 35 cases of hypotransferrinemia having TIBC less than 200 μg/dl were found in 600 determinations: 60% in 35 cases were blood diseases, 37% were malignancies, 20% were the diseases of digestive organs, including 2 cases of protein losing gastroenteropathy.
The radioassay method of TIBC was very useful for clinical transferrin assay.
