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Volume 16, Issue 11
Displaying 1-8 of 8 articles from this issue
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[in Japanese]1975 Volume 16 Issue 11 Pages 1007-1035
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (2448K)
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Hiroshi SAITO1975 Volume 16 Issue 11 Pages 1036-1043
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSTotal iron-binding capacity of the serum (TIBC) was determined by radioassay method developed by Saito.
Fifty μg/dl (38 mg/dl as transferrin) of TIBC, which is as low as in the cases of congenital atransferrinemia was found in a patient having a high plasma RISA disappearance rate. A similar ferrokinetics pattern was observed between the present case and the cases of congenital atransferrinemia.
In addition, 35 cases of hypotransferrinemia having TIBC less than 200 μg/dl were found in 600 determinations: 60% in 35 cases were blood diseases, 37% were malignancies, 20% were the diseases of digestive organs, including 2 cases of protein losing gastroenteropathy.
The radioassay method of TIBC was very useful for clinical transferrin assay.View full abstractDownload PDF (598K) -
—with Special Reference to the Effects of Prostaglandin E2 on Platelet Aggregation and Serotonin Release—Ryukichi Ryo, Kojiro YASUNAGA1975 Volume 16 Issue 11 Pages 1044-1049
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSFour patients with thrombasthenia have been investigated. All patients had impaired platelet aggregation induced by ADP, epinephrine and collagen, decreased platelet adhesiveness and deficient clot retraction. In all the patients, however, platelet serotonin release induced by collagen was normal. Further, platelets contained normal amounts of ADP, serotonin and c-AMP. The significance of these findings in relation to hemostasis in thrombasthenia is discussed.
Furthermore, the effects of PGE2 on platelet aggregation and serotonin release in all the patients were examined. PGE2 failed to augment platelet aggregation induced by ADP, epinephrine and collagen. In contrast, PGE2 slightly enhanced platelet serotonin release induced by collagen in 2 patients, but had no effect in the other. Thus it is not considered that PGE2 is useful in the treatment of bleeding in a patient with thrombasthenia.View full abstractDownload PDF (530K)
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Haruya YOSHIKAWA, Hideo TAKEYAMA, Junzo ISHIGURO, Kazumasa YAMADA, Mas ...1975 Volume 16 Issue 11 Pages 1050-1058
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of leukemic reticuloendotheliosis supposed to be chronic type was reported.
The patient (29-year old male) was admitted with chief complaints of nasal bleeding, general malaise and high fever. A huge spleen, pancytopenia and hypercellular bone marrow with maturation arrest were the most striking findings in physical and laboratory examinations on admission. The administration of betamethazone resulted in the temporary disappearance of the splenomegaly which reappeared after tapering down the drug.
Four months later, splenectomy and liver biopsy were performed, when 10% of atypical lymphoid cell was seen in the peripheral blood and 9.2% in the bone marrow. The portal pressure was normal and histology of the spleen showed atrophy of white pulp and infiltration of small to mediumsized mononuclear cells mainly in red pulp. Liver biopsy also showed diffuse scattering of simillar cells in the sinusoids.
Six months after splenectomy, he was readmitted because of progressive hepatomegaly and leucocytosis, when more than 90% of atypical lymphoid cell was seen both in the peripheral blood and the bone marrow. Cytological studies including electronmicroscopic and phase contrast microscopic examinations revealed the proliferating cells to be consistent with those of leukemic reticuloendotheliosis, and combination chemotherapy (VENP) was started. Four months later, hematological complete remission was obtained, which lasted for 6 months.View full abstractDownload PDF (1099K) -
—Studies on Hematopoietic Stem Cells and Erythropoietin Production—Takuo SHIRAKURA, Shinsuke TASAKI, Yoshiroh MURAI, Toshio TAKEDA1975 Volume 16 Issue 11 Pages 1059-1063
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA seventy-year-old man diagnosed as drug-induced aplastic anemia was presented. After admission to the authors' clinic, a treatment with a large dose of anabolic steroids, oxymetholone and methenolone, was instituted for aplastic anemia. Five months later the patient suddenly developed proteinuria (up to 31 g/day), hyperlipidemia, slight hypertension and subsequent hypoproteinemia. Renal function was quite normal. No elevation of BUN and creatinine was observed. However, the degree of pancytopenia was gradually enhanced, and ferrokinetic studies revealed a markedly decreased erythropoiesis. Erythropoietin (EPO) titers both in serum and urine were markedly high at any time before and after the renal involvement, while responsiveness of bone marrow cells to EPO was rapidly decreased. It was thought that the decrease in ERC brought about the lowering of erythropoiesis.
The pathogenesis of the “nephrotic syndrome” occurred under administration of a large dose of anabolic steroid was not evident. But this brief report seems to give a warning against anabolic steroid therapy.View full abstractDownload PDF (367K) -
Ryuzo KOYAMA, Harutaka ITAYA, Osamu NAKAZAWA, Atsushi KONDO, Yoshifumi ...1975 Volume 16 Issue 11 Pages 1064-1071
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of chronic lymphosarcoma cell leukemia of apparent B-cell origin is reported in this paper. The patient, a 19-year-old male, was admitted to our clinic because of lassitude and generalized lymphadenopathy with abnormal lymphocytosis.
The peripheral blood findings on admission revealed severe anemia and remarkable leukocytosis with ninty-five per cent of atypical lymphocytes. These atypical lymphocytes were larger and more variable in size with round, oval or notched nucleoli showing a reticular or spongy nuclear chromatin pattern. A sternal aspirate revealed markedly hypercellularity with diffuse proliferation of atypical lymphocytes.
In the examination of surface markers, the majority of the cells disclosed the existence of surface-associated heavy chain and kappa-light chain receptors. Sixty-seven per cent of the cells also had receptors for modified component of complement.
Complement dependent cytotoxicity using rabbit anti-human B-cell serum was determined by trypan blue dye exclusion test and cytotoxic indecies of the cells were 100%. These data indicated that lymphocyte proliferation of the case presented here was due to the cells with surface characteristics of B cells.
On the other hand, these cells could not respond to T-spesific stimulants and binding of 125I-labeled PHA to them was same to lymphocytes from normal individuals.
Finally, the clinical, laboratory and histopathological findings in the case of chronic lymphosarcoma cell leukemia were discussed.View full abstractDownload PDF (873K) -
Kazuo KOIKE, Akira HATTORI, Suiko ITO, Tsuneyasu TSUKADA, Matsuzo MATS ...1975 Volume 16 Issue 11 Pages 1072-1078
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA case of primary myelofibrosis was reported. A 52-year-old man was admitted to the Niigata University Hospital because of abdominal swelling and pain in December 1968. He had leuco-erythroblastic anemia and marked hepatosplenomegaly. Bone marrow puncture yielded no aspirate. Ferrokinetic study showed ineffective erythropoiesis and extramedullary hematopoiesis. Bone marrow biopsy revealed fibrosis. Splenectomy was performed in March 1971. The spleen weighed 4,000 gm. and measured 30×19.5×12 cm. Extramedullary hematopoiesis was observed in the spleen, the liver and the lymph nodes. After the splenectomy severe anemia and marked increase of both platelets and nucleated cells in the peripheral blood were evident. In March 1972, huge subcutaneous hematoma in the back appeared following strenuous muscle movements, and then hemolytic reaction occured after incompatible blood transfusions. Irregular antibodies including anti-E, anti-c and anti-Jkb antibodies were detected by serological examinations.
On the other hand, deformed spherocytes and spheric erythroblasts with a few hollows on the surface were observed by scanning electron microscopy. Suddenly, in November 1974, the patient was complicated by transverse myelopathy (Xth thoracic segment).
But he has survived for 52 months since the splenectomy.View full abstractDownload PDF (929K) -
—The Schilling Type Monocytic Leukemia—Akihiro KADONO, Shigeru SUGINO, Shinichi MISAWA, Hiroshi ANDACHI, Tats ...1975 Volume 16 Issue 11 Pages 1079-1088
Published: 1975
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 71 year old woman who complained of weakness and fever was reported as a case of leukemic reticuloendotheliosis. Abnormalities of anemia and splenomegaly were detected in physical examinations. However, hepatomegaly and lymphadenopathy were not detected. The laboratory results were as follows: Red Blood Cells (RBC) 244×104, Ht. 18%, White Blood Cells (WBC) 4800 with 52% of the leukemic reticulum cells atypical. The bone marrow N. C. C. was 70,000 with an 84% leukemic cell abnormality rate. The leukemic cells were large sized (40 μ in diameter) but no cytoplasmic projection such as the “hairy cell” was observed even with the phase contrast microscope. The chromatin of the nuclei was very fine and two or three nucleoli were observed. The peroxidase reaction was negative and the PAS reaction was positive. Phagocytosis was observed, but erythrophagocytosis was not demonstrated. After the woman died an autopsy was conducted. It was found that the spleen was hypertrophic and had a heavy infiltration of leukemic cells. The liver, kidneys, and lymphnodes were also infiltrated, but there was no solid tumor discovered in any tissue. The morphogical changes caused by the leukemic infiltration in the red pulp of the spleen were relatively predominant.
The investigating physicians considered this case to be a Schilling Type Monocytic Leukemia, or one of leukemic reticuloendotheliosis.View full abstractDownload PDF (1099K)
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