抄録
A case of chronic lymphosarcoma cell leukemia of apparent B-cell origin is reported in this paper. The patient, a 19-year-old male, was admitted to our clinic because of lassitude and generalized lymphadenopathy with abnormal lymphocytosis.
The peripheral blood findings on admission revealed severe anemia and remarkable leukocytosis with ninty-five per cent of atypical lymphocytes. These atypical lymphocytes were larger and more variable in size with round, oval or notched nucleoli showing a reticular or spongy nuclear chromatin pattern. A sternal aspirate revealed markedly hypercellularity with diffuse proliferation of atypical lymphocytes.
In the examination of surface markers, the majority of the cells disclosed the existence of surface-associated heavy chain and kappa-light chain receptors. Sixty-seven per cent of the cells also had receptors for modified component of complement.
Complement dependent cytotoxicity using rabbit anti-human B-cell serum was determined by trypan blue dye exclusion test and cytotoxic indecies of the cells were 100%. These data indicated that lymphocyte proliferation of the case presented here was due to the cells with surface characteristics of B cells.
On the other hand, these cells could not respond to T-spesific stimulants and binding of 125I-labeled PHA to them was same to lymphocytes from normal individuals.
Finally, the clinical, laboratory and histopathological findings in the case of chronic lymphosarcoma cell leukemia were discussed.
