抄録
A 71 year old woman who complained of weakness and fever was reported as a case of leukemic reticuloendotheliosis. Abnormalities of anemia and splenomegaly were detected in physical examinations. However, hepatomegaly and lymphadenopathy were not detected. The laboratory results were as follows: Red Blood Cells (RBC) 244×104, Ht. 18%, White Blood Cells (WBC) 4800 with 52% of the leukemic reticulum cells atypical. The bone marrow N. C. C. was 70,000 with an 84% leukemic cell abnormality rate. The leukemic cells were large sized (40 μ in diameter) but no cytoplasmic projection such as the “hairy cell” was observed even with the phase contrast microscope. The chromatin of the nuclei was very fine and two or three nucleoli were observed. The peroxidase reaction was negative and the PAS reaction was positive. Phagocytosis was observed, but erythrophagocytosis was not demonstrated. After the woman died an autopsy was conducted. It was found that the spleen was hypertrophic and had a heavy infiltration of leukemic cells. The liver, kidneys, and lymphnodes were also infiltrated, but there was no solid tumor discovered in any tissue. The morphogical changes caused by the leukemic infiltration in the red pulp of the spleen were relatively predominant.
The investigating physicians considered this case to be a Schilling Type Monocytic Leukemia, or one of leukemic reticuloendotheliosis.
