抄録
Peculiar inclusion bodies were demonstrated in the myeloblasts of both peripheral blood and bone marrow from a 17 year-old female, suffering from acute myeloblastic leukemia. This patient treated by Daunorubicine, Cytocine-arabinoside, 6-MP and corticosteroids, gained 11 months complete remission and survived 24 months after onset of the illness.
The light microscopy of the myeloblasts with May-Grunwald Giemsa stain showed small red granules, Auer rods, and several vacuoles in the cytoplasm.
By electron microscopy, 39% of the myeloblasts had one or several round vacuolar inclusion bodies, from 0.1μ to 4μ in diameter in the cytoplasm. They were located near the nucleus and had a limiting membrane, and contained fine granules, filaments, crystalloids, or a membranous substance besides a small amount of floccular material. In the cytoplasm of some myeloblasts another type of large electron dense granules were found and they were suggested to be giant azurophilic granules associated with acute granulocytic leukemia.
These vacuolar inclusions were suspected to be possibly secondary lysosomal in nature.
