赤白血病の鉄代謝

—Whole Body Linear Scanningを中心として—

抄録

Ferrokinetic studies with a whole body monitoring were performed in 11 patients with erythroleukemia at erythremic stage.
The results were as follows: PID T1/2 72±28 (mean±S. D.) min., RCU 10.5±10.3%, PIT 1.62±0.53 mg/kg/day and EIT 0.19±0.20 mg/kg/day. A significant correlation was observed between EIT and the numbers of circulating reticulocytes (r=+0.938), and between PIT and hemoglobin value (r=-0.684). However, no correlation was observed between serum iron and PID T1/2 value.
The distribution patterns of the erythropoietic marrows in 7 cases of erythroleukemia were evaluated with a ring-type whole body linear scanning using ⁵⁹Fe. In those 7 cases, the patterns of longitudial scan from head to foot at 24th hour after injection of ⁵⁹Fe which reflect the erythropoitic marrow distribution were classified into 3 types, that is, the type of erythroid hyperplasia or expansion of bone marrow (4 cases), the type of extramedullary erythropoiesis (2 cases) and the type of erythroid hypoplasia and deposition of ⁵⁹Fe in the liver (3 cases at leukemic stage or after blood transfusion). Judging from the distribution patterns of ⁵⁹Fe at 10th day, the retention of ⁵⁹Fe in the bone marrow was observed in 5, hemolysis in 4 and the iron deposition in the liver in all 7 cases.
The ferrokinetic indices and the distribution patterns of ⁵⁹Fe became to be normalized in two cases which acquired complete remission at leukemic stage after chemotherapy or bone marrow transplantation.