白血病性胸膜炎，脊髄対麻痺とともに再発し，AAAP療法が著効を奏した急性リンパ性白血病の1例

抄録

A case of acute lymphocytic leukemia relapsed with leukemic pleuritis and paraplegia was reported.
A 46-year-old female was admitted to our hospital because of hemorrhagic tendency. Examination of the blood showed hemoglobin, 5.2 g/dl; leukocytes, 4,600/cmm with 9% lymphoblasts; and platelets, 26,000/cmm. A sternal marrow aspiration revealed 91.2% lymphoblasts in the myelogram. A complete remission for 2 months was induced by VENP-therapy. Then, relapse occurred with leukemic pleuritis and complete transverse spinal palsy at the 5th to 6th thoratic segment. AAAP-therapy (ACNU 50 mg d.i./day×4, adriamycin 30 mg i.v./day×4, methotrexate 10 mg i.v. & 15 mg i.t. on day 1 and 4 and prednisolone 60 mg i.v./day×4) was indicated and soon after one course of this therapy, pleural effusions disappeared and hematological complete remission was reattained. Furthermore she was able to walk without crutches for 4 months despite of repeated hematological relapses and pleural effusions.
Thus, AAAP-therapy was revealed one of excellent chemotherapies for paraplegia complicated with acute leukemia.