抄録
An autopsy case of 74-year-old male with immunoblastic lymphadenopathy is reported. The patient had fever, cough, rapid enlargement of generalized lymph nodes, splenomegaly and hypergammaglobulinemia (IgG, IgA, IgM). A lymph node biopsy was performed and he was treated with vincristine and predonisolone. Though temporary favorable progress, his course was one of progressive deterioration, with death occurring six months after the onset of symptoms.
A biopsy specimen of lymph node showed a morphologic triad: proliferation of arborizing small vessels; prominent immunoblastic proliferations; and amorphous acidophilic interstitial material. At autopsy, generalized lymph nodes showed cellular depletion and a prominent deposit of acidophilic interstitial material. A very small amount of immunoblast were found here and there only in lymph nodes and spleen. Electron microscopic study demonstrated that there were much fibrous long spacing type of collagen fibril in the acidophilic interstitial material.
