抄録
This is a retrospective multi-center study as to the effect of androgenic hormones in 72 courses of treatment with anabolic hormones (AH), in 88 with these hormones combined with glucocorticoids (GCC) and in 183 with GCC as control. Each lineal regression was calculated in the course of Hb level, WBC and platelet count (as an indicator of erythrocytic, leukocytic and thrombocytic element respectively) in the courses of treatment with hormones. A positive slope of lineal regression was defined as effective in the hormone therapy. However, the courses with less than 30% decrease of the total transfused blood in the second half of a course from the first among transfused group with positive slope, were excluded from the effective courses.
AH was more effective on erythrocytic element (p<0.01) at the 4 months' (53.7%) and at the 6 months' observation (70.9%) than GCC (38.1 and 40.2%). Effect of AH was superior in female on erythrocytic element to in male at the age of below 39. In female, it was stronger on erythrocytic and thrombocytic element at the age of below 39 than at the age of above 40. It was of interest that AH was more effective in the courses with lower hematologic values in any of three elements than with higher values at the initiation of treatment. The effectiveness of AH was not so much affected by doses (below vs above 900 mg/month) or pre-treatment period time (<6 months vs 7 months<).
