輸血例における抗血小板同種抗体の経時的変化とリンパ球交差反応性について

抄録

Antiplatelet alloantibody (APA) was determined with Karpatkin's modified method, immune adherence hemagglutination method and mixed hemadsorption method, and antilymphocyte antibody (ALA) was determined with cytotoxicity test in cases given blood transfusion. APA and ALA appeared in 14 and 12 out of 34 cases given whole blood, 3 and 2 out of 4 cases given platelets, 1 and 2 out of 2 cases given leukocytes, respectively, but did not appeared in 7 cases given leukocyte-poor red blood cells and 8 cases given fresh frozen plasma. The appearance rates of APA or ALA were increased as the amounts of blood transfusion were increased. APA appeared 2∼4 weeks after the initiation of transfusion in cases with duration of transfusions within 8 days, and 5∼7 weeks after in cases with duration of transfusions over 9 days.
The latter cases showed highter titer of APA. Most of these APA and ALA were common antibodies to both to platelets and lymphocytes, and these ALA differed from ALA in systemic lupus erythematosus or polyarteritis nodosa. On the other hands, antibodies not common to platelet and lymphocyte antigen did exist. These indicates varieties of APA or ALA in polytransfused cases.