The levels of three components of F·VIII, ie, VIII: C, VIII R: AG and VIII R: WF were measured in 106 patients with liver diseases.
The values of VIII: C were variable, and there was only one patient having a weak VIII: C inhibitor (0.75 u/ml).
VIII R: AG levels were remarkably elevated in many cases, especially in hepatoma and decompensated liver cirrhosis.
The amount of VIII R: AG was correlated with γ-gl value in liver diseases. Abnormal electrophoretic mobility of VIII R: AG was seen in some patients with liver disease by crossed immunoelectrophoresis (0.27±0.4, Normal 0.24±0.02).
The value of VIII R: WF showed also high level as that of VIII R: AG, but two cases with persistent hepatitis were revealed to have similar data to von Willebrand's disease.
In vitro studies, VIII R: WF activity were neutralized dose dependently by γ-gl.
VIII: C/VIII R: AG ratio was about 0.5 in recovery stage of acute hepatitis, persistent hepatitis, chronic hepatitis and compensated liver cirrhosis. This low value was also found in hemophilia A carrier, so careful consideration should be paid in differentiating hemophilia A carriers and patients with liver diseases, particularly with combind affectious.
VIII R: WF/VIII R: AG ratio was inversely proportional to plasma γ-gl value, and this ratio could be employed to investigate functional abnormalities of HMW portion of F-VIII.
