A case of 47 years old woman with chronic granulocytic leukemia who developped additional karyotype abnormalities at the last stage of the disease was reported in the present communication. She visited the hematological clinic in July 1977 after she was administered Busulfan for 2 years. In December 1977, she was admitted under the diagnosis of acute crisis of chronic granulocytic leukemia without any additional karyotype anomaly to the Philadelphia (Ph1) chromosome and received some cytostatic agents such as cytosine arabinoside (Ara-C), Daunorubicine (DNR), Vincristine (VCR), and so on as presented in Fig. 2, while she had only moderate anemia and thrombocytopenia for eight months. After then, she had severe anemia and thrombocytopenia and showed 17 isochromosomes in addition to the Ph1 chromosome.
Furthermore, we discussed the correlation of survival time and the type of additional chromosome anomalies to the Ph1 chromosome after the crisis of chronic granulorytic leukemia.
