鉄欠乏性貧血の治療経過中における骨髄可染鉄と血清フェリチン値の関係—血清フェリチン値による貯蔵鉄評価の試み

抄録

This study was arranged to determine whether serum ferritin level was useful to evaluate an improvement of iron store by oral iron therapy in patients with iron deficiency anemia (IDA). Serum ferritin level, transferrin saturation and bone marrow iron deposit in 12 patients with IDA were studied before the treatment, on improvement of the anemia and after the treatment. Serum ferritin level and transferrin saturation increased significantly along with the course of treatment and the former showed a positive correlation with the latter (r=0.73, p<0.001). After the treatment bone marrow iron appeared to be normal in all cases, but on improvement of the anemia no iron deposit was found in any cases. 31 cases of bone marrow study were performed altogether and were devided into two groups; normal bone marrow iron group and depleted group. Serum ferritin levels of the latter were apparently dissociated from those of the former at the boundary level of approximately 20ng/ml, although transferrin saturation of the several cases in both groups overlapped each other. These findings suggest that serum ferritin level reflects bone marrow iron deposit more accurately than transferrin saturation does. It was considered that serum ferritin level is clinically useful to evaluate the improvement of bone marrow iron store by oral iron therapy.