全身性エリテマトーデス患者末梢血のT細胞subsetsの変動

抄録

The quantitative alteration of T cell subsets was studied on peripheral blood lymphocytes from 20 patients with systemic lupus erythematosus (SLE) and compared with those of 25 healthy adults. Four patients were clinically inactive and 16 were active SLE. Six patients with active SLE were not treated before the study. T Lymphocytes were enumerated as rosette formed cells with sheep erythrocytes. Tγ and Tμ cells were detected by using rosette technique with bovine erythrocytes coated either with IgG or IgM antibodies.
The proportion and absolute count of T cells were significantly decreased in SLE (p<0.01). Moreover, the total number and percentage of Tγ cells were remarkably reduced (p<0.001). Although the absolute number of Tμ cells significantly diminished (p<0.01), the proportion remained within the control range. The total count of T non γ non μ cells, which are T cells not possessing Fc receptors for IgG and IgM on their cell surface, were not significant between SLE patients and healthy controls. However, the percentage of T non γ non μ cells was higher than control (p<0.05). These disproportions of T cell subsets were not statistically significant between active and inactive SLE. The ratio of Tγ/Tμ cells, however, was significantly lower in active SLE (p<0.01).