This paper presents a case of T-cell lymphoma with a long survival achieved by radiation and immunochemotherapy.
A 46 year old male, a non-native of Kyushu district, was admitted to our service for the further evaluation and treatment of subcutaneous tumor of r. shoulder and l. arm on January 1979. Two years prior to admission the patient was diagnosed as malignant lymphoma from the histological findings of dissected nasal septal tumor, which was treated by irradiation therapy alone. A tumor of the r. inguinal region was extripated for further evaluation and was diagnosed as poorly differentiated malignant lymphoma. These tumor cells formed rosette with sheep erythrocytes. Bone marrow aspiration revealed hypocellularity without tumor cells and he was treated by prednisolone alone with poor response and additional local administration of OK-432 was started into the tumor which became soften in consistency and decreased in size. Positive direct Coomb's test and antiplatelet antibody were detected in short time of thrombocytopenia, and the increased administration of prednisolone improved the platelet counts. In spite of immunochemotherapy including prednisolone, Bleomycin, oil-Bleo and OK-432, the tumor size was increased and symptom was aggravated and expired on March 1979 due to shock induced by oil-Bleo injection.
Through the clinical evaluation of this patient, it is emphasized that 28 months long survival was achieved responding to the treatment with irradiation and local OK-432 administration. This case of T-cell lymphoma suggested the effectiveness of the combined therapy with irradiation and immunopotenciator.
