抄録
A 59-year-old man with multiple myeloma is reported. Examinations performed on admission revealed the presence of both IgG myeloma protein and Bence Jones protein of λ type in the serum, whereas no Bence Jones protein in the urine. This Bence Jones protein was a tetramer of λ type light chains physiochemically. Evidences of gelatinous bulky clots, impaired clot retraction and prolonged thrombin times were noted. Electron microscopic study revealed the disturbance of fibrin clot formation seemed to be due to the interference of the M protein with fibrin aggregation—α-α and γ-γ cross-linkages. Significant increase in the number of the T cells seemed to suggest the relation to the immaturity of the myeloma cells.
