抄録
A 69-year-old male was admitted to Tukuba University Hospital because of leukocytosis on April 28, 1978. Physical examination was unremarkable without hepatosplenomegaly. Peripheral blood count showed leukocytosis including immature granulocytes and basophils. Bone marrow study revealed markedly increased myeloid cells in all stages of development. Neutrophil alkaline phosphatase stain was positive in 72% of WBC and the score was 137 which was lower limit of the normal range. The karyotype of bone marrow cells was [45, X, Ph1 (+)]. White cells in the peripheral blood, cultured with PHA, and skin fibroblasts showed the karyotype of normal male, [46, XY]. Accordingly, the diagnosis of CML with Ph1 and missing Y chromosome was established. He was observed without medication because of flucuating WBC between 30,000 and 40,000/cmm and no splenomegaly. There has been no evidence suggesting blastic crisis until present time (January, 1980).
