抄録
Increasing frequency of cases with malignant lymphomas following autoimmune diseases and experimental studies on New Zealand black mice suggest an immunological relationship between autoimmune diseases and the development of malignant lymphomas. We report a case of malignant lymphoma occurring subsequent to autoimmune hemolytic anemia.
Case T.O., a 60-year-old housewife, was first seen at the Second Tokyo National Hospital in June 1979, complaining of general fatigue and exertional palpitation. Examinations revealed anemia, marked reticulocytosis, erythroid hyperplasia of the bone marrow, diminished serum haptoglobin and positive direct and indirect antiglobulin tests. Neither splenomegaly nor lymphadenopathy was found. Anemia was recovered by corticosteroid therapy. In September 1979, when she suffered from herpes zoster, the indirect antiglobulin test became negative. In July 1980, she noticed the swelling of her left lower jaw and biopsy revealed malignant lymphoma of diffuse mixed type. After radiation the swelling subsided and she is now well.
