1981 年 22 巻 3 号 p. 285-290
The relationship between the degree of the initial hematological impairment and the survival terms was analysed in 190 cases of aplastic anemia registered by the Ministry of Health and Welfare Specific Disease (aplastic anemia, idiopathic hematological disorders) Research Committee using the criteria for grading the severity of this disorder which had been reported by us.
In terms of the degree of the initial hematological impairment, 190 cases were divided into 3 groups: 76 cases (40.0%) were severe, 79 cases (41.6%) were moderate, and 35 cases (18.4%) were mild. Survival rates for these 3 groups were clearly different at any time throughout the follow-up period. The mortality rates evaluated at the 6th month after the onset of symptoms were 55.3% in severe, 17.7% in moderate, and 0% in mild cases. On the contrary, survivors for more than 5 years after the onset of symptoms were 15.8% in severe, 55.7% in moderate, and 80.0% in mild cases respectively.
The results of the present study clearly show the closed correlation between the degree of the initial hematological impairment and the survival periods of the patients with aplastic anemia. Thus, grading of the severity using the criteria reported by us would help us to estimate the prognosis of the patients with aplastic anemia.