This paper describes a case of leukemic non-Hodgkin lymphoma (diffuse poorly differentiated lymphocytic type). The patient was treated with the combination of daunorubicin, cyclophosphamide, vincristine and prednisolone (DCOP), getting complete remission, and survived for 13 months, although its prognosis has been recognized to be very poor. The effectiveness of daunorubicin was confirmed in the clinical course of this case, therefore daunorubicin was regarded as one of the drugs of choice for the treatment of non-Hodgkin lymphoma, though it required the accumulation of cases.
Disseminated intravascular coagulation (DIC) observed in this case was fluctuated in the course of this case, especially of the leukemic state. These phenomena suggested that DIC in malignant lymphoma might be correlated to the pathophysiological situations as exacerbation or remission during chemotherapy with special reference to the presence of the coagulants in lymphoma cells.
