抄録
An autopsy case with adult T-cell leukemia was reported. A 43 year-old who came from yonezawa city was admitted to our hospital with chief complaints of hepatosplenomegaly and pancytopenia. At this time, there were no leukemic changes in peripheral blood or bone marrow, and no lymphadenopathy. After plateletkinetics, splenectomy was performed, because thrombocytopenia was due to enlarged spleen which was shown to be congested with a weight of 3420 gr and was no evidence of leukemic infiltration. Peripheral blood picture recovered in normal range immediately after the splenectomy. Leukocytosis with prolymphocytes was recognized from 8th month after splenectomy. Besides the prolymphocytes, abnormal mononuclear cells with convoluted or lobulated nuclei were recognized about 10% in peripheral blood. Both these abnormal cells were T-cell origin. Bone marrow aspirate showed normocellular feature with 96.8% for leukemic cells. The leukemic cells in peripheral blood responded slightly to corticosteroid, cyclophosphamide and vincristine therapy. Thes case was diagnosed to be adult T-cell leukemia with prolymphocytes and convoluted lymphocytes.
Autopsy revealed slight leukemic cell infiltration in various organs, lymphadenopathy in thoracic and peritoneal cavity and hypocellular bone marrow. Pathological diagnosis was adult T-cell leukemia.
