抄録
A considerable number of the patients with primary malignant diseases now achieve prolonged disease-free survival from their onset. It is possible that anticancer therapy, both chemotherapy and radiotherapy, may be causally related to the development of acute leukemia as a second malignancy. Acute leukemia as a late complication of anticancer therapy, mostly granulocytic, is characterized by a low remission rate and extremely short survival.
Case 1: A 44-year-old female. In 1968, a diagnosis of right breast cancer was made and a radical mastectomy was performed. A histological diagnosis was ductal carcinoma. Postoperatively, she recieved a chemotherapy of triethylene thiophosphoramide with a total dosis of 150mg. In December 1974, she was admitted to our hospital because of high fever. She was diagnosed as acute lymphocytic leukemia and died of intestinal bleeding after nine months.
Case 2: A 53-year-old female. In May 1973, she was diagnosed as cervical cancer. The panhysterectomy and the postoperative 60Co therapy with a total of 3,488 rad was performed. In March 1979, she admitted to our hospital because of anemia and high fever. A diagnosis of acute myelogenous leukemia was made and she died of sepsis after two months. In both cases, postmortem examination revealed no residue of the primary malignacies.
One may that the occurrence of the acute leukemia after the treatment of cancer is only conicidental. But the present report clearly indicated the need of the careful follow-up of the long-term survivors who have recieved cancer therapy.
