An adult case of acute erythroblastopenia (AEP) with cytomegalovirus infection and autoimmune disturbance is reported.
A 30-year-old woman came to our hospital because of fever and general fatigue. Physical examination revealed no positive finding. Hematological examination showed RBC 515×104/μl, Hb 15.8 g/dl, reticulocyte 1‰, WBC 2,500/μl and platelet 7.2×104/μl. Sternal bone marrow examination revealed almost complete absence of erythroid elements and presence of a few giant proerythroblasts.
After 7 days, a complete recovery of erythropoiesis in the bone marrow was shown.
Preceding cytomegalovirus infection was considered on the basis of rising anticytomegalovirus antibody titer. In addition, a transient autoimmune disturbance as indicated by high titers of antinuclear antibody and anti-DNA antibody was also revealed.
Relationship between the viral infection with autoimmune diturbance and etiology of AEP was discussed.
