A long survivor of ALL who showed overt CNS-leukemia and 8 hematological relapses durng 12 years is reported. A 9-year-old boy was admitted to our hospital in October, 1970 with the presenting symptoms of easy fatigability and paleness of the face. A diagnosis of ALL was made and the patient was placed on a combination chemotherapy of DVP, which brought a complete remission in January, 1971. Twenty-three months later the patient developed overt CNS-leukemia. Being treated with frequent intrathecal chemotherapy and irradiation, the patient had leukoencephalopathy as permanent sequela. From that time on, the patient repeated 8 hematological relapses in October, 1973, September, 1976, May, 1978, November, 1979, October, 1980, February, 1981, December, 1981 and July, 1982. After 12 years under therapy the patient died of sepsis in October, 1982.
