抄録
In three cases with ITP with inadequate response to high-dose corticosteroid administration splenectomy was sucessfully done after an increase in the platelet counts following the high-dose intravenous administraion of IG-100 (Sandoglobulin).
They were with 45, 27, and 22 years of age. Duration of the illness ranged between three months to fourty years. A diagnosis of ITP was made based upon a markedly reduced platelet count, increase in marrow megakaryocytes and shortened platelet life span.
IG-100 was administered in a dose of 400 mgm/kg/day for consecutive five days. Immediate and remarkable rise in the platelet counts were observed and after a splenectomy further rise in the platelet counts and the prolongation of the platelet life span followed in all the three cases.
The dose of orally administrered coricosteroid was gradually diminished, and the platelet counts have been within normal limits. In two of them no steroid is prescribed at present.
