The Clinicopathological features of 51 patients with untreated megaloblastic anemia due to vitamin B12 deficiency were analysed. The material consisted of 40 patients with Addisonian pernicious anemia (PA), 10 with postgastrectomy B12 deficiency (PG) and one with blind-loop syndrome. No sex preponderance was noted in PA patients with mean age of 63 years. Mean Broca's indices for PA and PG patients were 88.9% and 77.2%, respectively, showing a poorer nutritional status in PG patients. The mode of onset, clinical symptoms, hematological findings including bone marrow morphology, blood chemistry, ferro-erythrokinetic data and nervous system involvement were all essentially analogous in PA and PG patients. The spleen was palpably enlarged in 25% of PA patients at diagnosis. The correlations between various laboratory parameters were examined.
