抄録
Among 15 patients with ALL, 4 patients with blastic crisis of CML and 10 patients with non-Hodgkin lymphoma who received several courses of combination chemotherapy including vincristine or vindesine, 4 patients showed a transient and repeated indirect hyperbilirubinemia corresponding to the vinca alkaloid administration. Hyperbilirubinemia appeared after 4-5th injection in 3 cases and it was evidint following the first administration in a remaining case. Serum bilirubin reached the peak concentration on 2-3 days after vinca alkaloid injections and returned to normal within 5-7 days. Slight reticulocytosis was observed in two cases. On the other hand, the levels of serum LDH, GOT, GPT and Al-P remained within normal limits. Scince the administration of vinca alkaloid alone in these patients resulted in a similarly transient elevation of indirect bilirubin, it was presumed that the observed hyperbilirubinemia might represent a vinca alkaloid-induced hemolytic reaction.
