The effect of methylprednisolone on disseminated intravascular coagulation (DIC) was investigated in 3 DIC cases developed from abdominal aortic aneurysm (case 1), peritonitis carcinomatosa due to gastric cancer (case 2) and miliary tuberculosis (case 3). The diagnosis of DIC and severity were graded based on the “DIC team” scoring system.
After the administration of methylprednisolone, each case recovered from DIC as judged by the scores: from 8 to 5 (case 1), from 7 to 5 (case 2) and from 7 to 0 (case 3), respectively. In the case 3 with miliary tuberculosis, therapeutic effect of methyl-prednisolone was enhanced by the simultaneous use of FOY.
The present investigation suggested that administration of methylprednisolone is useful in the treatment of DIC by itself, or by the combination of anticoagulant therapy.
