進行非ホジキンリンパ腫のVCP療法耐性症例に対するABP療法

抄録

From May 1977 to April 1982, a combination chemotherapy consisting of adriamycin, bleomycin and prednisolone (ABP therapy) was applied for 22 patients with advanced non-Hodgkin's lymphoma, resistant to VCP (vincristine, cyclophosphamide and prednisolone) therapy.
Histological types by Rappaport classification were 15DHL, 3DPDL, 3DML and 1DUL, and clinical stages 8III and 14IV.
Twenty patients were evaluable. Complete remission (CR) was obtained in 10/20 patients (50%), and partial remission in 6/20 (30%). The median time to reach CR was 16 days (7-56) and the median duration of CR 19 months (3-67+).
The median survival time was 9.5 months (2-69+) for all patients, 26 months (5-69+) for patients with CR and 5.5 months (2-12) for patients who had partial or no remission.
The results suggested that there was no cross-resistance between VCP and ABP.