抄録
A 12-year-old boy was admitted in January 1981, because of high fever, left cervical lymphadenopathy, and massive splenomegaly. He was diagnosed as having Hodgkin's disease of mixed cellularity, stage IIIsB. By the treatment with CHOP and irradiation on the left neck, remission was achieved.
In July 1981, the disease relapsed. Following the ABVD therapy of two months and splenectomy, he began to complain of headache and vomiting. Lumbar puncture revealed a cell count of 500/cumm with 62% atypical lymphoid cells. He was treated with intracranial methotrexate and craniospinal irradiation, and achieved a remission in November 1981.
The spinal fluid obtained at a regular examination in September 1982 contained 539/cumm cells with 80% atypical lymphoid cells. Immunological markers of the spinal fluid cells were examined, which showed E-rosette formation (63%) and positive reaction against 80% for Leu 1, 10% for Leu 2, and 62% for Leu 3. These data were consistent with those of meningeal involvement of Hodgkin's disease. He got a remission again with intrathecal MTX and Ara-C, and 23 months after the last remission, he is completely free from the disease.
