Hypereosinophilic Syndromeの病態

—好酸球性白血病の位置づけ—

抄録

The hypereosinophilic syndrome (HES) represents a group of disorders with the common features of prolonged eosinophilia of an undetectable causes and organ system dysfunction. The clinical and laboratory findings of HES in 26 patients reported in Japanese literature were reviewed. We can subdivide them into at least two groups. The first is a group of patients who have non-specific elevation of various serologic titers to suggest an immunological response. The second group have morphological abnormalities of the eosinophiles associated with immature forms, biochemical evidences, ie., B₁₂, neutrophil alkaline phosphatase, and cytogenetics, to suggest that they truely have a myeloproliferative disorder. Numerous evidences that support the existence of hematologic malignancies affecting eosinophilic series in HES have been provided. These may be best called eosinophilic leukemia. We describe a case with HES which does not fall into both subgroups mentioned above and show the heterogeneity of HES.