抄録
A 25-yr-old Japanese female in 18-wk gestation was admitted on July 9, 1982 with a 2-wk history of general malaise and low-grade fever. On admission, peripheral blood examination revealed anemia (Hb 8.7 g/dl) and leukocytosis (WBC 20,300/cmm) with 52% leukemic cells. These leukemic cells were identified as lymphoblasts with T-cell phenotype. A diagnosis of T-cell acute lymphoblastic leukemia was made. Chest X-ray and echocardiogram showed pericardial effusion, in which a number of lymphoblasts were found. After received therapeutic artificial abortion, she was treated with an induction regimen consisting of daunomycin, adriamycin, vincristine, cyclophosphamide. L-asparaginase, cytocine arabinoside and prednisolone as well as intrapericardial administration of methotrexate. After 6 courses of treatment, complete remission was achieved on her 52th hospital day. She is alive without any signs of relapse. Prior to therapy, cytogenetic analysis revealed a consistent chromosome rearrangement; 46, XX, t (5; 12) (q35; q13).
