白血病の生物学的免疫学的，治愈のアプローチ

抄録

In a biological viewpoint, a leukemic cell may be regarded as an abnormal cell deviated from a normal differentiation of hematopoiesis.
We succeeded in inducing an in-vitro differentiation of four in-vitro cultured leukemic cell lines (HL 60, NKM-1, U 937, KG-1) when treated with either retinoic acid (RA) and/or γ-interferon (γ-IF) or TPA. During this differentiation, antigeneic alterations on the surface of leukemic cells were examined with a panel of monoclonal antibodies named “HHM” series, which were produced in our laboratory and all of which are specific to myeloid cells. As a result, the cell surface antigens recognized by those antibodies varied qualitatively and quantititively in an accordance with the distribution of those antigens which were previously attested in various differentiation steps of normal hematopoietic cells. Amongst these findings, it is interesting that the antigen detected by HHM 5 antibody is expressed more while the one detected by HHM 6 and 7 antibody exists less on the cell surface as the leukemic cells mature in a vitro.