抄録
11 Cases of aortic aneurysm including 3 cases of dissecting aneurysm and 8 cases of cardiac aneurysm, in whom typical consumption coagulopathy was observed, were presented. Mean age (±SD) of these was 79.8±11.0. In these cases, platelet counts and levels of fibrinogen, plasminogen and antithrombin III in plasma decreased, concentration of FDP in plasma increased, and prothrombin times prolonged. Euglobulin lysis times of these patients varied a great deal. The courses of these cases were generally long and abnormal hemostatic findings frequently improved following the administration of small doses of heparin (less than 10,000 units per day). Marked hemorrhagic symptoms were observed in only a few case, notwithstanding the fact that obivious consumption coagulopathy was present. Clinically, thrombotic symptoms, for example cerebral and/or renal infarction were more important. In a case of left cardiac aneurysm, multiple infarctions of the lungs developed. 4 cases among 11 ones of aortic aneurysm, complicated with local DIC, died of rupture of the aneurysm. In general, oral anticoagulant therapy was not effective in these patients, however an improvement of coagulation findings followin the administration of warfarin was observed in a patient of cardiac aneurysm.
