Hematological malignancies with hypercalcemia in our clin during these fifteen years were evaluated.
Among 364 cases of the whole hematological malignancies, the cases which were beyond 11 mg/dl of serum Ca level were 17 ones just as follows.
Leukemia cases: Only 3 of 226 cases (1.3%) which included a case of chronic myelogenouse leukemia in blastic crisis and 2 cases of adult T cell leukemia (ATL). Malignant lymphoma cases: 6 of 108 cases (4.9%), which were all non Hodgkin lymphoma at the clinical stage IV. Myeloma and its related disorders cases: 8 of 30 cases (26.7%), which included 2 cases of IgG κ type, a case of IgG λ type, 2 cases of IgA κ type, a case of Bence Jones protein (BJP) κ &λ type and a case of non secretory κ type.
By the combined therapy with anticancer chemotherapy, prednisolone, saline infusion and diuretics, furethermore partly with addsion on thyrocalcitonin, serum calcium level was corrected transiently in 15 cases of 17 ones.
Throughout clinical coure, renal failure and hyperuricemia was observed except for 2 cases as a complication of hematological malignancies with hypercalcemia. Pulmonary edema was observed in 8 cases as the cause of death.
Median survival term after the onset of hypercalcemia was 3.4 months.
The causative mechanism of hypercalcemia in the hematological malignancies studied this time was not clarified clearly but it was considered that bone resorption by the direct infiltration of tumor cells into bone might play a principal role of hypercalcemia.
