剖検時細菌検査からみた造血器腫瘍における感染症の起炎菌の推移

—特に真菌とグラム陽性球菌の増加傾向について—

抄録

1. Postmortem bacteriological studies were performed on 100 cases of hematological malignancies during the period from 1980 to 1984.
Most common pathogens isolated from heart blood were pseudomonas, enterococcus and candida, while those from long tissue were pseudomonas, candida and staphylococcus.
Compared with the results obtained during the period from 1970 to 1979, E. coli and klebsiella were isolated less frequently. The isolations of fungus from heart blood and of staphylococcus from lung tissue were increased in incidence after 1980.
2. Histological examinations of 83 autopsy cases showed high incidence (37.3%) of systemic fungal infection, very high (55.9%) in neutropenic cases.
3. Prophylactic oral administration of anti-fungal agents (mostly amphotericin B) reduced the incidence of fungal infections of the alimentary tract. Aspergillosis was particularly less frequent among prophylactic group.
Prophylactic inhalation of amphotericin B reduced the incidence of systemic fungal infection, especially of candidiasis.