An 83 year-old-woman was admitted to the hospital on Oct. 1984 because of anorexia, constipation and weight loss. Physical examinations revealed a mass on the right lateral abdomen. A computerized tomography of abdomen showed an irregular mass in the right kedney. The white blood cell count was 40,100/μl with 25% band forms, 52% segmented forms, 14% eosinophils and 5% lymphocytes. Cytologic study of a bone marrow (BM) aspirate showed myeloid hyperplasia. The CFU-GM was 45.3/2×105 BM cells. The white blood cell count rose to 84,500/μl and the patient died on Dec. 17, 1984. At autopsy, metastatic carcinoma was found in the liver, kidney, pancreas, lymph node, lung but not in BM. The histological diagnosis of the tumor was pleomorphic carcinoma of the kidney.
CSF was studied using non-adherent cells from normal human bone marrow as target. CSF activity were demonstrated in the ascites and the tumor extract from the autopsy materials. These findings indicated that the tumor cells produced CSF in vivo.
