臨床研究
Non-Hodgkin's Lymphoma 46小児例の治療成績
1986 年 27 巻 4 号 p. 480-487
詳細
1986 年 27 巻 4 号 p. 480-487
From Nov. 1971 to Feb. 1985, 46 children with non-Hodgkin's lymphoma (NHL) were treated at the Kanagawa Children's Medical Center. Murphy's staging was used. Patients with more than 25% blasts in the bone marrow were included under the diagnosis of NHL as Lymphoma-Leukemia syndrome (LLS). Thirteen patients admitted from 1971 to 1976 (group A) were treated with a treatment regimen for acute lymphoblastic leukemia; 14 patients from 1977 to 1981 (group B) with the NHL1 protocol; 8 patients from 1982 to 1985 (group C) with the NHL2 protocol consisting of high dose (HD) MTX, HD-Endoxan, HD-cytosine-arabinoside, adriamycin, prednisolone and vincristine. Survival and continuous complete remission (CCR) rates were calculated by Kaplan-Mier method.
Initial complete remission rates in group A, B, C and LLS were 62%, 71%, 100% and 73%, respectively. Three year survival rate in group A was 7.7% (SE 7.4), and in group B+C was 50.5% (SE 12.3). Although 2-year-CCR rate in group A was 0%, it was 71.1% (SE 12.4) in group B+C. Differences in survival and CCR rates among these groups were statistically significant. In groups B+C and LLS, 3-year-CCR rate of stage I+II was 100%, but those of stage III+IV and LLS were 60.6% (SE 18.4) and 0%, respectively.
This study indicates that intensive chemotherapy can produce long-term remission in 70% of children with NHL.
