A 50-year-old female was admitted to Narita Red Cross Hospital on Feb 28, 1983, because of recently developed jaundice and general malaise. A diagnosis of acute hepatitis was made. Pancytopenia developed since Mar 11, and she was referred to Chiba University Hospital, where a diagnosis of post-hepatitis aplastic anemia with septicemia of E. Coli was made. Laboratory findings were as follows; GOT 57 mu/ml, GPT 176 mu/ml, LDH 164 mu/ml, T. Bil 22 mg/dl, D. Bil 14.3 mg/dl, WBC 300/cmm, Hb 11.3 g/dl, Plt 7.3×104/cmm, Ret 0.2%. Bone marrow was hypoplastic.
The patient was treated with plasma exchange, granulocyte transfusion and administration of antibiotics. She gradually recovered from pancytopenia since the beginning of April.
Hematopoietic progenitor cells [CFU-C, CFU-E, BFU-E] were assayed and followed with her hematological recovery. Inhibitory activity against hematopoietic progenitor cells was detected in her onset serum.
