A 48 year old man was admitted on December 15, 1984 with general malase and easy fatigability. Physical examination revealed anemia, icterus, splenomegaly and a few swollen lymph nodes. Peirpheral blood examination showed anemia (Hb. 6.7 g/dl) and reticulocytosis (17.6%). High level of serum bililubin and LDH, and marked decrease of haptoglobin were observed. Both direct and indirect Coombs test were positive and autoantibody was in an IgA type. On bone marrow aspiration, hand mirror like lymphocytes were noted. The lymphonode biopsy specimen diclosed malignant lymphoma, diffuse medium sized cell type. Phenotype of lymphocyte in lymph node was OKT8 positive and OKT4 negative.
He was treated with vincristine, cyclophosphamide, predonisolone and adriamicin. After 4 corses of treatment, partial remission was achieved. At present, he has been remained on regimen 10 mg of predonosolone and his condition has been well controlled.
