抄録
A-45-year old woman was admitted to the National Defense Medical College Hospital in January 1984 because of high fever. She had experienced the symptom repeatedly since August 1982 and had absolute monocytosis (WBC 8,000/mm3, monocyte 39.5%) with hypercellular bone marrow (NCC 60.5×104/mm3).
The peripheral blood showed Hb 5.5 g/dl, RBC 201×104/mm3, reticulocytes 4.0%, platelets 33×104/mm3 and WBC 7,500/mm3 with 25% of monocytes. A bone marrow smear was normocellular but showed various morphological abnormalities in myelocytes, erythroblasts and megakaryocytes. Combined esterase stains were positive in 11.5% of myeloid or monocytoid cells in bone marrow. Serum V.B 12 level was elevated. Serum and urinary lysozyme levels were not increased. NAP score was markedly low. Bone marrow culture for CFU-C was not obtained.
She was diagnosed as CMML and treated with low-dose cytosine arabinoside unsuccessfully and died of pneumonia in September 1984.
Cytogenetic studies on two different occasions showed a loss of chromosome 7 without any other abnormality.
