症例
血清中にBFU-Eに対する抑制因子の存在を認めた幼児一過性赤芽球減少症の1例
1986 年 27 巻 9 号 p. 1688-1692
詳細
1986 年 27 巻 9 号 p. 1688-1692
A 2-year-old boy was admitted to Tokushima University Hospital because of pallor in January 1984. The diagnosis of transient erythroblastopenia of childhood was made from severe microcytic anemia, reticulocytopenia and erythroblastopenia. Spontaneous recovery was seen about one week after initial diagnosis, without corticosteroid therapy.
In order to determine the mechanism of anemia, we evaluated the marrow cell erythropoiesis in vitro and its effect of the serum. The number of burst-forming units-erythroid (BFU-E) in the bone marrow of the patients was increased and become normal at recovery. The patient's serum at initial stage suppressed the growth of normal and patient's BFU-E and the suppression was no longer present after the erythroblastopenia had remitted. These findings suggest the transient immune suppression of erythroid colony development.
