We reported a 43-year-old man diagnosed as adult T-cell leukemia with scirrhous-like lesion of the stomach. He was admitted because of epigastralgia, systemic lymphadenopathy and eczema on the extremities. Hemogram in admission showed that white blood cells count were 48,200/mm3 with 65% abnormal lymphocytes. These abnormal lymphocytes showed indented or lobulated nuclei and mature T cell phenotypes (E (+), OKT3 (-), OKT4 (+)). Anti-ATL associated antigen (ATLA) antibody was positive. The diagnosis of adult T-cell leukemia was made. A scirrhous-like lesion was revealed in the stomach by X-ray examination. Histological examination of the biopsied specimens from stomach revealed an infiltration of leukemic cells into the entire mucous membrane and submucosal tissue. Scirrhous-like lesion of the stomach in patient with ATL was discussed.
