Etoposide (NK-171)単独療法のみで寛解しえた，巨大肝内腫瘤を呈したATLの1例

抄録

A 58-year-old female was hospitalized because of right epigatric pain. The white blood cell count was 30,400/mm³, showing 64% of abnormal lymphocytes.
Hypercalcemia was noted, and anti-ATLA antibodies were 160 fold. The surface character of lymphocyte was OKT 4⁺, 8^-, Tac⁺. Huge intrahepatic tumor was noted, the biopsy revealed ATL infiltration. After single treatment with etoposide, the level of calcium became normalized, the intrahepatic tumor and abnormal lymphocytes disappeared almost completely, and a state of abatement was obtained.
Intrahepatic lesion of ATL rarely presents huge localized lesions as in this case. Abatement was obtained with Etoposide therapy alone without performing intensive chemotherapy. The case continued to survive for a relatively long period.