抄録
Recent molecular biologic interpretation of the Philadelphia (Ph1) translocation in chronic myelogenous leukemia (CML) was reviewed. The halmark of Ph1 chromosome in CML has been identified as a reciprocal translocation, i.e., t (9; 22) (q34; q11) in most cases of CML. In their leukemia cells, it has been shown that the c-abl gene (normally locates at 9q34) is transposed to 22q11 region which contains 5.8 kb breakpoint cluster region with the DNA rearrangments. According to this transposition, the message of c-abl gene altered to a larger fragment than the normal, and which hybridize with the 5' bcr probe, resulting in a chimeric bcr/c-abl mRNA. We presented here recent interpretation of this change in CML with unusual Ph1 translocations or “masked” Ph1 chromsomes.
