加齢，老化と血液

抄録

Changes in coagulability, fibrinolytic activity and viscosity of blood, related to age were investigated in healthy subjects. The results were as follows: Factor VIII activity and plasma fibrinogen content increased with age, however factor V activity were lower in aged subjects. Activities of factors X and VIII, and levels of fibrinogen, antithrombin III and plasminogen in plasma were higer in the young male than in the age-matched female, although those were lower in the aged male than in the female with corresponding age. Von Willebrand factor in plasma were assayed in the aged subjects and was higher in male than in female. Hematcrit values and blood viscosity were higher in the male than in the female, in general. Hematcrit values tended to decline with age, although blood viscosity were higher in the aged subjects. From these results, it seems to be reasonable to conclude that aged male is Slightly thrombotic than age-matched female. This may contribute to longevity of female.