症例
著明な低ガンマグロブリン血症をともない，小腸浸潤による大量消化管出血をきたした成人T細胞性白血病の1剖検例
1988 年 29 巻 1 号 p. 39-43
詳細
1988 年 29 巻 1 号 p. 39-43
A 52-year-old male born in Hokkaido was admitted to Sapporo City General Hospital because of fever, bleeding tendency and general malaise on May 26, 1986. Hematological examination revealed pancytopenia. The leukocyte count in peripheral blood was 1,100/μl, with 25% abnormal lymphocytes showing convoluted or lobulated nuclei. Serum anti-ATLA antibody was positive with titer of 1:40 (IF) and 1:1024 (PA). The expression of ATLA by short-term culture of leukemic cells was detected. Leukemic cells had T cell markers (Leu 2a(-), Leu 3a(+), Leu 4(+)). Serum immunoglobulin concentration was marked reduced (Ig G 502mg/dl, Ig A 37.9mg/dl, Ig M 73.0mg/dl).
On the 26th hospital day, he was died owing to the massive melena with small intestine involvement. Postmortem examination showed extensive infiltration of leukemic cells in small intestine, generalized lymphnodes, liver and spleen.
