抄録
A five-year-old girl with prulent meningitis due to Hemophilus influenzae was treated with Latamoxef, 260mg/kg/day, which induced agranulocytosis. Latamoxef was discontinued. She was referred to our hospital for the management of agranulocytosis in a clean room. Three days after discontinuation of Latamoxef the granulocytes began to appear in the peripheral blood. After recovery from agranulocytosis the influence of Latamoxef on the growth of bone marrow granulocytemacrophage progenitor cells was examined using in vitro colony assay (CFU-C). Latamoxef significantly inhibited CFU-C growth in concentrations from 4×10-5 to 4×10-8 mol/l. The addition of patient's serum collected during the agranulocytic period did not inhibit colony growth further. The serum antineutrophil antibody and HLA antibody were not detected. Latamoxef did not stimulate patient's lymphocyte blastogenesis.
