臨床研究
慢性リンパ性白血病患者のB細胞コロニー形成におよぼす患者T細胞の影響
1988 年 29 巻 7 号 p. 1036-1040
詳細
1988 年 29 巻 7 号 p. 1036-1040
We studied the effect of T cells on the growth of B-chronic lymphocytic leukemia (B-CLL) colonies using on in vitro assay B cell colonies were induced by PHA and colony-stimulating factors, which were the culture supernatants conditioned by PHA, activated monocytes and T cells. Colonies of more than 50 cells were counted under a dissecting microscope. Cells in the colonies from B-CLL patients were morphologically similar to the circulating leukemic cells.
The phenotypic expression of T cells was analyzed in three untreated patients with B-CLL. The result was low Leu3a-Leu2a ratios. T cells from B-CLL patients supressed B-CLL colonies less than to the extent of normal T cells.
