症例
多彩な好中球の形態および機能異常を呈し播種性アスペルギルス症にて死亡したMyelodysplastic Syndromeの1例
1988 年 29 巻 7 号 p. 1060-1065
詳細
1988 年 29 巻 7 号 p. 1060-1065
A 50-year-old woman was admitted to our department because of myelodysplastic syndrome (MDS). Bone marrow showed normocellurality and myeloid hyperplasia with 8.8% of myeloblasts. Peripheral blood examination revealed pancytopenia and WBC 2,000/μl with 1% of myeloblast. PMN were deficient not only in granules and staining reactivity for myeloperoxidase and alkaline phosphatase but also in superoxide production.
These cells inefficiently killed both Streptococcus faecalis and Staphylococcus aureus in vitro.
She died of pulmonary insufficiency and autopsy revealed disseminated aspergillosis and diffuse pulmonary alveolar proteinosis. Marked functional defects in intracellular killing system of PMN as presented here will be one of the most important prognostic factors in patients with myelodysplastic syndrome.
